| Primary Identifier | MGI:2137612 | Organism | mouse, laboratory |
| Chromosome | 5 | NCBI Gene Number | 94244 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables Hsp90 protein binding activity. Involved in several processes, including protein folding; regulatory ncRNA-mediated gene silencing; and spermatogenesis. Located in cytosol and synaptonemal complex. Is expressed in brain; genitourinary system; intestine; liver; and skin. Human ortholog(s) of this gene implicated in Williams-Beuren syndrome and spermatogenic failure 77. Orthologous to human FKBP6 (FKBP prolyl isomerase family member 6 (inactive)). PHENOTYPE: Mice homozygous for a knock-out allele exhibit azoospermia and male infertility associated with arrest of male meiosis at the pachytene stage, and increased apoptosis of meiotic spermatocytes. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
