Primary Identifier | MGI:1919291 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 72041 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables broad specificity oxidative DNA demethylase activity. Involved in positive regulation of gene expression, epigenetic. Predicted to be located in cytoplasm and nucleolus. Predicted to be active in contractile ring and midbody. Orthologous to human ALKBH4 (alkB homolog 4, lysine demethylase). PHENOTYPE: Mice homozygous for a targeted mutation exhibit lethality prior to weaning. Mice homozygous for a floxed allele activated in mouse embryonic fibroblasts exhibit decreased migration and impaired cytokinesis. [provided by MGI curators] |