Primary Identifier | MGI:2685899 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 381678 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables histone reader activity and methylated histone binding activity. Involved in meiosis I; positive regulation of DNA metabolic process; and spermatogenesis. Acts upstream of or within homologous chromosome pairing at meiosis. Located in XY body and nucleus. Is expressed in brain; lung; reproductive system; and thymus. Orthologous to human ZCWPW1 (zinc finger CW-type and PWWP domain containing 1). PHENOTYPE: Mice homozygous for a knock-out allele exhibit male and female infertility due to arrested male meiosis and premature ovarian insufficiency. [provided by MGI curators] |