Primary Identifier | MGI:2176213 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 170935 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in regulation of postsynaptic cytosolic calcium ion concentration and regulation of postsynaptic membrane neurotransmitter receptor levels. Acts upstream of or within long-term synaptic depression. Located in synapse. Is active in cerebellar granule cell to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and postsynaptic density, intracellular component. Orthologous to human GRID2IP (Grid2 interacting protein). PHENOTYPE: Mice homozygous for a knock-out allele display facilitated long-term depression induction at parallel fiber-Purkinje cell synapses as well as enhanced optokinetic response adaptation. [provided by MGI curators] |