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Protein Coding Gene : Cyth3 cytohesin 3
Primary Identifier  MGI:1335107 Organism  mouse, laboratory
Chromosome  5 NCBI Gene Number  19159
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables phosphatidylinositol-3,4,5-trisphosphate binding activity. Acts upstream of or within establishment of epithelial cell polarity and positive regulation of cell adhesion. Located in several cellular components, including adherens junction; bicellular tight junction; and ruffle. Is expressed in brain. Orthologous to human CYTH3 (cytohesin 3).
PHENOTYPE: Mice homozygous for a null allele do not develop overt diabetes but do show reduced insulin receptor signaling in liver and adipose tissue. Under aging conditions or a high-fat diet, homozygotes show decreased weight gain with a significant reduction of body fat due to increased lipid excretion. [provided by MGI curators]
  • synonyms:
  • pleckstrin homology, Sec7 and coiled-coil domains 3,
  • Grp1,
  • Cyth3,
  • Pscd3,
  • AI648983,
  • cytohesin 3,
  • expressed sequence AI648983,
  • MGI:2140949
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Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

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4 Pathways

Trail: ProteinCodingGene

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Gene --> Protein-Protein Interactions

Expression

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Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

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