Primary Identifier | MGI:1196224 | Organism | mouse, laboratory |
Chromosome | 5 | NCBI Gene Number | 264064 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Part of mediator complex. Is expressed in embryo; tibialis anterior; and tongue. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human CDK8 (cyclin dependent kinase 8). PHENOTYPE: Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction. [provided by MGI curators] |