| Primary Identifier | MGI:101927 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 13396 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including embryonic morphogenesis; positive regulation of epithelial cell proliferation; and roof of mouth development. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; brain; branchial arch; limb; and sensory organ. Used to study split hand-foot malformation 1. Orthologous to human DLX6 (distal-less homeobox 6). PHENOTYPE: Homozygotes for targeted null mutations at both Dlx5 and Dlx6 exhibit bilateral ectrodactyly, homeotic transformation of the lower jaw into an upper jaw, and perinatal lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
