| Primary Identifier | MGI:2153588 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 140491 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable glycogen binding activity; protein phosphatase 1 binding activity; and protein serine/threonine phosphatase activity. Predicted to be involved in regulation of glycogen biosynthetic process. Predicted to act upstream of or within glycogen metabolic process. Predicted to be located in membrane. Predicted to be part of protein phosphatase type 1 complex. Used to study type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in hypoglycemia and type 2 diabetes mellitus. Orthologous to human PPP1R3A (protein phosphatase 1 regulatory subunit 3A). PHENOTYPE: Homozygous mutant mice have reduced levels of skeletal muscle glycogen. Whereas one model was normoglycemic and grossly normal, another on a similar genetic background was glucose intolerant, insulin resistant, and gained weight to the point of obesity. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
