| Primary Identifier | MGI:98954 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 22413 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable cytokine activity and frizzled binding activity. Involved in cell proliferation in midbrain and positive regulation of neurogenesis. Acts upstream of or within several processes, including circulatory system development; lung induction; and positive regulation of cell population proliferation. Predicted to be located in collagen-containing extracellular matrix; cytoplasm; and extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including embryo mesenchyme; heart and pericardium; reproductive system; upper jaw primordium; and urethra. Human ortholog(s) of this gene implicated in breast carcinoma; hepatocellular carcinoma; and urinary system cancer. Orthologous to human WNT2 (Wnt family member 2). PHENOTYPE: Homozygous mutants exhibit impaired placental vascularization, runting and 50% perinatal mortality resulting from difficulties in breathing and nursing. Survivors of the perinatal period tend to recover, and adults are healthy and fertile. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
