| Primary Identifier | MGI:97816 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 19283 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein tyrosine phosphatase activity. Involved in several processes, including oligodendrocyte differentiation; peptidyl-tyrosine dephosphorylation; and regulation of myelination. Acts upstream of or within axonogenesis and hematopoietic progenitor cell differentiation. Located in perineuronal net and plasma membrane. Is active in synapse. Is expressed in several structures, including central nervous system; cranial nerve; eye; genitourinary system; and limb. Orthologous to human PTPRZ1 (protein tyrosine phosphatase receptor type Z1). PHENOTYPE: Mice homozygous for targeted null mutations demonstrate an impaired ability to recover from inflamatory lesions of the CNS or gastric mucosa. Mice homozygous for a knock-out allele exhibit increased tactile and thermal nociception thresholds. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
