Primary Identifier | MGI:99434 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 11844 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP binding activity. Predicted to be involved in intracellular protein transport and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to act upstream of or within protein transport. Located in cytoplasm and plasma membrane. Is expressed in cerebral cortex; cerebral cortex intermediate zone; cerebral cortex ventricular zone; and cortical plate. Orthologous to human ARF5 (ARF GTPase 5). PHENOTYPE: Mice homozygous for a null allele exhibit no abnormalities. Mice also heterozygous for an arf4 null allele exhibit impaired coordination, tremors and altered brain wave pattern and Purkinje cell electrophysiology. [provided by MGI curators] |