| Primary Identifier | MGI:1351317 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 27205 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in several processes, including negative regulation of cell-cell adhesion; regulation of microvillus assembly; and regulation of synapse assembly. Acts upstream of or within leukocyte migration. Located in apical plasma membrane and microvillus membrane. Is active in glutamatergic synapse and presynaptic membrane. Is expressed in several structures, including genitourinary system; integumental system; intraembryonic coelom; nervous system; and sensory organ. Orthologous to human PODXL (podocalyxin like). PHENOTYPE: Mice homozygous for a knock-out allele exhibit neonatal lethality and severe kidney defects including absence of the podocyte slit diaphragm and foot processes and anuria. While a subset display edema and/or omphalocele, most mice appear normal at birth. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
