Primary Identifier | MGI:2141558 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 101240 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatidylinositol 3-kinase inhibitor activity. Predicted to be involved in early endosome to late endosome transport and regulation of protein catabolic process. Predicted to be located in cytosol and endosome membrane. Predicted to be active in early endosome membrane and late endosome membrane. Orthologous to human WDR91 (WD repeat domain 91). PHENOTYPE: Mice homozygous for a null alle exhibit neonatal lethality associated with intraabdominal bleeding. Mice homozygous for a conditional allele activated in neurons exhibit premature death, decreased brain size and weight, neuron apoptosis and reduced complexity and length of neurites. [provided by MGI curators] |