| Primary Identifier | MGI:2443430 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 320127 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables ATP-dependent diacylglycerol kinase activity; GTPase inhibitor activity; and small GTPase binding activity. Involved in presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including chemical synaptic transmission; habituation; and modulation of chemical synaptic transmission. Located in perinuclear region of cytoplasm. Part of guanyl-nucleotide exchange factor complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in cerebral cortex; cerebral cortex mantle layer; and cerebral cortex marginal layer. Orthologous to human DGKI (diacylglycerol kinase iota). PHENOTYPE: Mice homozygous for a knock-out allele appear normal and do not develop tumors after wound induction or exposure to PMA. Mice homozygous for a different knock-out allele show increased body fat mass and percent body fat/body weight, decreased bone mineral density and increased plasma glycerol level. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
