Primary Identifier | MGI:1914623 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 67373 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables serine-type endopeptidase activity. Acts upstream of or within zymogen activation. Predicted to be active in extracellular space. Is expressed in ductus deferens; gallbladder; pancreas; pancreas tip epithelium; and testis. Used to study pancreatitis. PHENOTYPE: Mice homozygous for an autoactivated allele are runted and die by 2 months of age. Mice heterozygous for the allele develop acute and chronic pancreatitis. [provided by MGI curators] |