Primary Identifier | MGI:1918876 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 231931 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP binding activity. Acts upstream of or within several processes, including autophagy; cell redox homeostasis; and defense response to other organism. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system. Orthologous to human GIMAP6 (GTPase, IMAP family member 6). PHENOTYPE: Conditional homozygous knockout in lymphocytes affects autophagy and mitophagy in peripheral T cells and increases apoptosis and decreases the numbers of these T cells. [provided by MGI curators] |