| Primary Identifier | MGI:2442232 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 317757 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable GTP binding activity. Predicted to be involved in several processes, including negative regulation of metabolic process; positive regulation of lymphocyte mediated immunity; and regulation of T cell activation. Predicted to be located in lysosomal membrane and multivesicular body membrane. Human ortholog(s) of this gene implicated in portal hypertension. Orthologous to several human genes including GIMAP5 (GTPase, IMAP family member 5). PHENOTYPE: Mice homozygouse for a knock-out allele display defects in lymphocyte development with hematopoietic defects and reduced life span. Mice homozygous for an ENU-induced allele exhibit premature death associated with extramedullary hematopoiesis in the liver, anemia, cachexia, and colitis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
