Primary Identifier | MGI:1889206 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 54353 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within negative regulation of cell population proliferation. Located in cytoplasm. Is expressed in cerebral cortex ventricular layer and cortical plate. Orthologous to human SKAP2 (src kinase associated phosphoprotein 2). PHENOTYPE: Mice homozygous for a null allele are embryonic lethal. Homozygotes for a gene-trapped allele show impaired B-cell responses and B-cell adhesion, decreased susceptibility to EAE, abnormal dendritic cell physiology, fast extinction of fear memory, and impaired social memory. [provided by MGI curators] |