Primary Identifier | MGI:1889842 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 58909 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human FAM13A (family with sequence similarity 13 member A). PHENOTYPE: Homozygotes for a null allele are resistant to cigarette-induced emphysema. Homozygotes for a different null allele show impaired insulin signaling in WAT and enhanced lipolysis leading to exacerbated WAT inflammation, high FFA levels, glucose intolerance and insulin resistance under high-fat diet. [provided by MGI curators] |