| Primary Identifier | MGI:1860374 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 56150 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein homodimerization activity. Involved in negative regulation of apoptotic process and positive regulation of mitotic cell cycle spindle assembly checkpoint. Acts upstream of or within mitotic sister chromatid segregation and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including kinetochore; nucleus; and spindle pole. Part of mitotic spindle assembly checkpoint MAD1-MAD2 complex. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). PHENOTYPE: Homozygous null embryos die at E6.5-7.5. At E5.5, embryonic cells assemble spindles and undergo mitosis but do not arrest in response to microtubule depolymerization. At E6.5, loss of a functional spindle assembly ckeckpoint results in widespread chromosome missegregation and apoptosis. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
