| Primary Identifier | MGI:96495 | Organism | mouse, laboratory |
| Chromosome | 6 | Mgi Type | gene segment |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within B cell differentiation. Predicted to be located in extracellular region and plasma membrane. Predicted to be part of IgG immunoglobulin complex and alpha-beta T cell receptor complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Orthologous to human IGKC (immunoglobulin kappa constant). PHENOTYPE: Homozygous inactivation of this gene prevents the expression of rearranged kappa genes, leading to exclusive production of lambda chain-expressing B cells and alterations in immunization titers, germinal center development, and somatic hypermutation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
