| Primary Identifier | MGI:97895 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 19692 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable several functions, including growth factor activity; identical protein binding activity; and peptidoglycan binding activity. Involved in several processes, including pancreas regeneration; phosphatidylinositol 3-kinase/protein kinase B signal transduction; and type B pancreatic cell differentiation. Acts upstream of or within with a positive effect on gene expression. Located in collagen-containing extracellular matrix. Is expressed in several structures, including esophagus; lung; and pancreas. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to several human genes including REG1A (regenerating family member 1 alpha). PHENOTYPE: Mice homozygous for a targeted null mutation appear normal. However, [3-H] thymidine incorporation into isolated pancreatic islets was reduced and GTG-induced islet hyperplasia was attenuated, suggesting a role for this gene in islet cell growth or regeneration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
