| Primary Identifier | MGI:1350935 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 21909 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within enteric nervous system development; mesoderm formation; and negative regulation of dendrite morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including adrenal gland; alimentary system; nervous system; primitive streak; and urinary system. Used to study intestinal pseudo-obstruction. Orthologous to human TLX2 (T cell leukemia homeobox 2). PHENOTYPE: Homozygotes for two targeted null mutations exhibit megacolon with hyperinnervated enteric ganglia which undergo neuronal degeneration. Homozygotes for a third null mutation die in utero with defects in formation of the primitive streak and mesoderm. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
