| Primary Identifier | MGI:2180021 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 246278 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables carbohydrate binding activity. Predicted to be involved in defense response to virus and immune response. Predicted to be located in plasma membrane. Predicted to be active in external side of plasma membrane. Is expressed in epidermis; lymph node; spleen; and thymus. Orthologous to human CD207 (CD207 molecule). PHENOTYPE: Nullizygous mice lack Birbeck granules with no marked loss of Langerhans cell (LC) function. Knock-in mice expressing diphtheria toxin (DT) receptors show LC depletion. Heterozygotes for a knock-in allele show DT-induced LC ablation, altered contact hypersensitivity and susceptibility to infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
