| Primary Identifier | MGI:2176159 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 232174 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; and retinoic acid binding activity. Involved in several processes, including cellular response to retinoic acid; positive regulation of tongue muscle cell differentiation; and tongue morphogenesis. Acts upstream of or within several processes, including cornification; establishment of T cell polarity; and establishment of skin barrier. Predicted to be located in cytoplasm. Is expressed in several structures, including brain; genitourinary system; heart and pericardium; limb; and sensory organ. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1). PHENOTYPE: Homozygous null mice typically show disrupted limb morphogenesis and proximal-distal patterning. Mutant mice are born but die immediately after birth exhibiting respiratory distress. Homozygotes for a null allele show abnormally enlarged aortic valves and ventricular septal defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
