| Primary Identifier | MGI:1913534 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 66284 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Acts upstream of or within several processes, including NLRP3 inflammasome complex assembly; neutrophil activation involved in immune response; and response to cortisol. Located in basal part of cell. Is expressed in reproductive system; stomach; trunk; and yolk sac. Orthologous to human GKN2 (gastrokine 2). PHENOTYPE: Homozygous null mice have impaired basal gastric epithelial differentiation and show accelerated progression to atrophic gastritis and metaplasia, hyperactivated Th1 immunity, increased mucosal innate immunity and impaired myeloid-derived suppressor cell responses after H. pylori infection. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
