| Primary Identifier | MGI:1338820 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 12154 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable receptor ligand activity; receptor serine/threonine kinase binding activity; and telethonin binding activity. Involved in several processes, including BMP signaling pathway; heart development; and positive regulation of cell population proliferation. Acts upstream of or within heart development; kidney development; and positive regulation of gene expression. Predicted to be located in Z disc and cell surface. Predicted to be active in extracellular space. Is expressed in several structures, including blood; heart; liver; lung; and metanephros. Used to study tetralogy of Fallot. Orthologous to human BMP10 (bone morphogenetic protein 10). PHENOTYPE: Homozygous null mice display decreased embryo size, cardiac dysgenesis, defects in early embryonic vascular development, enlarged pericardium, arteriovenous malformations, and embryonic lethality. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
