| Primary Identifier | MGI:1346042 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 23945 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables monoacylglycerol lipase activity. Involved in several processes, including monoacylglycerol catabolic process; regulation of endocannabinoid signaling pathway; and regulation of retrograde trans-synaptic signaling by endocanabinoid. Acts upstream of or within long-term synaptic depression and regulation of axon extension. Located in several cellular components, including cytosol; synapse; and varicosity. Is active in cerebellar climbing fiber to Purkinje cell synapse; parallel fiber to Purkinje cell synapse; and presynapse. Is expressed in several structures, including alimentary system; central nervous system; integumental system; respiratory system; and urinary system. Orthologous to human MGLL (monoglyceride lipase). PHENOTYPE: Mice homozygous for a gene trapped allele exhibit hypoalgesia, increased body temperature, and decreased fatty acid levels. Mice homozygous for a targeted allele exhibit impaired lipolysis and improved glucose homeostasis on a high-fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
