| Primary Identifier | MGI:107685 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 18844 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables semaphorin receptor activity. Involved in T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; nervous system development; and semaphorin-plexin signaling pathway. Acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching; neuron projection morphogenesis; and regulation of smooth muscle cell migration. Located in membrane. Part of semaphorin receptor complex. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; central nervous system; cranial nerve; genitourinary system; and sensory organ. Orthologous to human PLXNA1 (plexin A1). PHENOTYPE: Mice homozygous for a null allele exhibit bone cellularity abnormalities, altered dendritic cell physiology, abnormal proprioceptive and oligodendrocyte morphology, and increased lymphatic branching complexity and LEC numbers. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
