| Primary Identifier | MGI:1196356 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 232227 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein kinase binding activity. Involved in several processes, including positive regulation of focal adhesion disassembly; positive regulation of keratinocyte migration; and regulation of postsynaptic neurotransmitter receptor internalization. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density, intracellular component. Is expressed in central nervous system; forelimb muscle; sensory organ; and viscerocranium. Human ortholog(s) of this gene implicated in intellectual developmental disorder with short stature and behavioral abnormalities and lung adenocarcinoma. Orthologous to human IQSEC1 (IQ motif and Sec7 domain ArfGEF 1). PHENOTYPE: Mice homozygous for a conditional allele activated in neurons fail to exhibit mGluR- and NMDAR-mediated long term depression. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
