| Primary Identifier | MGI:1930008 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 58991 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable ghrelin receptor binding activity; growth hormone-releasing hormone activity; and protein tyrosine kinase activator activity. Involved in adult feeding behavior; positive regulation of appetite; and positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of insulin secretion; and positive regulation of synapse assembly. Located in cytoplasm and extracellular region. Is active in neuronal dense core vesicle lumen. Is expressed in several structures, including alimentary system; ear; genitourinary system; nervous system; and skeleton. Human ortholog(s) of this gene implicated in diabetic neuropathy; esophagus adenocarcinoma; morbid obesity; obesity; and type 2 diabetes mellitus. Orthologous to human GHRL (ghrelin and obestatin prepropeptide). PHENOTYPE: Mice homozygous for most disruptions in this gene display no phenotypic abnormalities on a regular diet and increased utilization of fat as an energy substrate on a high fat diet. Mice homozygous for one allele display age-dependent changes in stimulated food intake and metabolism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
