| Primary Identifier | MGI:1917887 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 232339 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in negative regulation of fat cell differentiation. Acts upstream of or within several processes, including glucose homeostasis; negative regulation of organ growth; and negative regulation of signal transduction. Located in actin cytoskeleton. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Used to study obesity. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to human ANKRD26 (ankyrin repeat domain containing 26). PHENOTYPE: Mice homozygous for a gene trapped allele have enlarged kidneys and hearts, exhibit increased lean body mass and adiposity, develop extreme obesity associated with hyperphagia rather than reduced energy expenditure, and show insulin resistance and gigantism. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
