Primary Identifier | MGI:99837 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 17836 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable endopeptidase inhibitor activity and protease binding activity. Acts upstream of or within embryo implantation. Predicted to be located in extracellular space. Is expressed in liver. Orthologous to human PZP (PZP alpha-2-macroglobulin like). PHENOTYPE: Mice homozygous for a knock-out allele are viable, fertile and phenotypically normal under standard conditions but show increased mortality in response to diet-induced acute pancreatitis along with hepatic cell necrosis and inflammatory infiltration, andincreased plasma amylase and lipase levels. [provided by MGI curators] |