Primary Identifier | MGI:1913287 | Organism | mouse, laboratory |
Chromosome | 6 | NCBI Gene Number | 56760 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable transmembrane signaling receptor activity. Acts upstream of or within platelet formation. Located in cell surface and plasma membrane. Is expressed in dorsal root ganglion; liver; lung; and spinal cord. Orthologous to human CLEC1B (C-type lectin domain family 1 member B). PHENOTYPE: Mice homozygous for a knock-out allele exhibit congestion and hemorrhages during embryogenesis with prenatal and postnatal lethality. Mice homozygous for another knock-out allele exhibit blood-lymph mixing, impaired PDPN-Fc-mediated platelet activation, and intestinal edema. [provided by MGI curators] |