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Protein Coding Gene : Borcs5 BLOC-1 related complex subunit 5
Primary Identifier  MGI:1915024 Organism  mouse, laboratory
Chromosome  6 NCBI Gene Number  67774
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Acts upstream of or within nervous system development and organelle transport along microtubule. Is active in axon and lysosome. Is expressed in brain; heart; lung; and metanephros. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to human BORCS5 (BLOC-1 related complex subunit 5).
PHENOTYPE: Homozygous knockout affects lysosomal transport in nerve fibers, leading to respiratory failure around birth and perinatal death. [provided by MGI curators]
  • synonyms:
  • 5830457J20Rik,
  • RIKEN cDNA 5830457J20 gene,
  • BLOC-1 related complex subunit 5,
  • Borcs5,
  • Loh12cr1,
  • AW124643,
  • loss of heterozygosity, 12, chromosomal region 1 homolog (human),
  • expressed sequence AW124643,
  • MGI:2141652
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