| Primary Identifier | MGI:2385261 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 232791 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Involved in positive regulation of cold-induced thermogenesis; regulation of stem cell population maintenance; and trophectodermal cell differentiation. Located in P-body. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and white fat. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). PHENOTYPE: Mice homozygous for a knock-out allele show defective outgrowth of the inner cell mass and complete embryonic lethality at implantation. Heterozygotes exhibit decreased cardiac muscle contractility and develop severe cardiomyopathy leading to heart failure in response to pressure overload. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
