| Primary Identifier | MGI:2682314 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 330474 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables chromatin binding activity. Involved in RNA catabolic process and negative regulation of DNA-templated transcription. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; oocyte; retina; and telencephalon. Orthologous to human ZC3H4 (zinc finger CCCH-type containing 4). PHENOTYPE: Embryos homozygous for a knock-out allele do not develop past blastocyst formation, fail to hatch from the zona pellucida or hatch but do not form typical outgrowth colonies, and show peri-implantation lethality, defective epiblast and primitive endoderm lineages, increased embryonic tissue cell apoptosis, and reduced cell proliferation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
