| Primary Identifier | MGI:103289 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 19698 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in circadian regulation of gene expression; negative regulation of DNA-templated transcription; and non-canonical NF-kappaB signal transduction. Acts upstream of or within T-helper 1 cell differentiation; antigen processing and presentation; and myeloid dendritic cell differentiation. Located in cytosol and nucleus. Is active in synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; liver; and lung. Used to study atopic dermatitis. Human ortholog(s) of this gene implicated in breast cancer and immunodeficiency 53. Orthologous to human RELB (RELB proto-oncogene, NF-kB subunit). PHENOTYPE: Mutant homozygotes die prematurely with phenotypes including inflammatory cell infiltration of organs, myeloid hyperplasia, splenomegaly, reduction in thymic dendritic cells, impaired cellular immunity, hyperkeratosis, epidermal hyperplasia, or hepatitiswith mononuclear infiltration. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
