| Primary Identifier | MGI:88598 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 13088 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable heat shock protein binding activity; heme binding activity; and monooxygenase activity. Acts upstream of or within response to bacterium. Predicted to be located in mitochondrial inner membrane. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Is expressed in several structures, including adrenal gland; gut; hemolymphoid system gland; liver; and lung. Human ortholog(s) of this gene implicated in several diseases, including acute myeloid leukemia; drug dependence (multiple); human immunodeficiency virus infectious disease; neonatal abstinence syndrome; and nicotine dependence. Orthologous to human CYP2B6 (cytochrome P450 family 2 subfamily B member 6). PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased levels of liver injury and steatosis after chronic-plus-binge ethanol administration with abnormal ethanol metabolism and alterations in hepatic and serum metabolites. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
