Primary Identifier | MGI:1346333 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 24030 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPS12 (mitochondrial ribosomal protein S12). PHENOTYPE: Mice homozygous for an error-prone encoding allele exhibit reduced mitochondrial translation and levels of complex IV, and increased polyploid cells in the liver, hepatocyte proliferation, and mitochondiral DNA content. Mice homozygous for a hyper-active encoding allele exhibit reduced mitochondrial translation and dilated cardiomyopathy. [provided by MGI curators] |