| Primary Identifier | MGI:1344360 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 23900 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable phosphatidylinositol 3-kinase binding activity; protein-macromolecule adaptor activity; and signaling receptor binding activity. Predicted to be involved in natural killer cell mediated cytotoxicity; positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; and protein phosphorylation. Predicted to be located in cell surface and membrane. Predicted to be active in plasma membrane. Is expressed in ductus deferens; epididymis; esophagus; prostate gland; and testis. Orthologous to human HCST (hematopoietic cell signal transducer). PHENOTYPE: Mice homozygous for a null allele exhibit osteopetrosis, decreased CD8+ T cells involved in tumor rejection, decreased uterine NK cells, and abnormal implantation site morphology. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
