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Protein Coding Gene : Psenen presenilin enhancer gamma secretase subunit
Primary Identifier  MGI:1913590 Organism  mouse, laboratory
Chromosome  7 NCBI Gene Number  66340
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0)

Enables endopeptidase activator activity. Involved in positive regulation of endopeptidase activity and protein processing. Acts upstream of or within Notch receptor processing. Part of gamma-secretase complex. Is expressed in early tubule; female associated reproductive structure; male associated reproductive structure; ovary; and testis. Human ortholog(s) of this gene implicated in hidradenitis suppurativa. Orthologous to human PSENEN (presenilin enhancer, gamma-secretase subunit).
PHENOTYPE: Homozygous mutation of this gene results in lethality before weaning. [provided by MGI curators]
  • synonyms:
  • Psenen,
  • RIKEN cDNA 1700023M09 gene,
  • presenilin enhancer gamma secretase subunit,
  • Pen2,
  • 1700023M09Rik
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Canonical gene --> Exons in specific strains

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21 Pathways

Trail: ProteinCodingGene

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