| Primary Identifier | MGI:2685324 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 233080 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables G protein-coupled receptor activity. Involved in several processes, including positive regulation of acute inflammatory response to non-antigenic stimulus; positive regulation of cytokine production; and regulation of secretion by cell. Acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; positive regulation of neuronal action potential; and regulation of heart rate by chemical signal. Is active in membrane. Is expressed in several structures, including adrenal gland; gut; peripheral nerve trunk; spleen; and sympathetic nervous system. Orthologous to several human genes including FFAR3 (free fatty acid receptor 3). PHENOTYPE: Mice homozygous for a null allele colonized with a model fermentative community are lean and exhibit decreased weight gain, increased intestinal transit rate, and reduced caloric extraction. Mice homozygous for a knock-out allele exhibit a slight increase in serum insulin when fed a high-fat diet. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
