| Primary Identifier | MGI:892019 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 16623 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides and serine-type endopeptidase activity. Acts upstream of or within several processes, including bradykinin biosynthetic process; left ventricular cardiac muscle tissue morphogenesis; and tissue kallikrein-kinin cascade. Predicted to be located in acrosomal vesicle; apical part of cell; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in extracellular space and secretory granule. Human ortholog(s) of this gene implicated in cardiomyopathy; chronic kidney disease; end stage renal disease; hypertension; and myocardial infarction. Orthologous to several human genes including KLK1 (kallikrein 1). PHENOTYPE: Homozygous null mice display decreased left ventricular contractility, cardiac output, and stroke volume, a thin left ventricular wall, and impaired vasodilation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
