| Primary Identifier | MGI:2182465 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 101568 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables protein phosphatase activator activity and protein phosphatase binding activity. Acts upstream of or within negative regulation of ERK1 and ERK2 cascade. Located in nucleus. Is expressed in several structures, including dorsal mesogastrium; hemolymphoid system; liver; metanephros; and yolk sac. Used to study autism spectrum disorder. Orthologous to human VRK3 (VRK serine/threonine kinase 3). PHENOTYPE: Mice homozygous for a null allele display impaired social behavior, decreased fear and anxiety relate behavior, impaired spatial memory, and abnormal hippocampal dendritic spine and synapse morphologies. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
