Primary Identifier | MGI:3039582 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 381983 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable protein kinase activity. Predicted to be involved in chromatin remodeling. Predicted to be located in Golgi membrane; axon; and dendrite. Is expressed in liver lobe and nervous system. Orthologous to human LMTK3 (lemur tyrosine kinase 3). PHENOTYPE: Mice homozygous for a knock-out allele exhibit pronounced behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior, an increased striatal dopamine turnover rate, and enhanced behavioral response to methylphenidate. [provided by MGI curators] |