| Primary Identifier | MGI:98796 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 21990 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables tryptophan 5-monooxygenase activity. Involved in platelet degranulation; regulation of hemostasis; and serotonin biosynthetic process. Acts upstream of or within bone remodeling; mammary gland alveolus development; and positive regulation of fat cell differentiation. Located in cytoplasm. Is expressed in several structures, including central nervous system; gut; ovary; retina; and trunk. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and nicotine dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1). PHENOTYPE: Mice homozygous for one null allele display no gross behavioral abnormalities. Mice homozygous for a second null allele display fatigue, breathing difficulties, progressive pallor, and impaired cardiac function. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
