| Primary Identifier | MGI:3689889 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 100040608 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Contributes to ubiquitin protein ligase activity. Acts upstream of or within several processes, including ovarian follicle development; protein ubiquitination; and spermatogenesis. Part of Fanconi anaemia nuclear complex. Used to study primary ovarian insufficiency. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group F; adenocarcinoma in situ; and granulosa cell tumor. Orthologous to human FANCF (FA complementation group F). PHENOTYPE: Mice homozygous for a knock-out allele exhibit small ovaries, abnormal estrous cycle, decreased primordial ovarian follicle number, azoospermia, increased ovary tumor incidence, increased gonadotropin levels, premature death and genomic instability in mouse embryonic fibroblasts. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
