Primary Identifier | MGI:1351867 | Organism | mouse, laboratory |
Chromosome | 7 | NCBI Gene Number | 108116 |
Mgi Type | protein coding gene |
description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Predicted to enable prostaglandin transmembrane transporter activity and sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in several processes, including positive regulation of NF-kappaB transcription factor activity; prostaglandin transport; and sodium-independent organic anion transport. Predicted to be located in basal plasma membrane. Predicted to be active in basolateral plasma membrane. Is expressed in nervous system and thyroid gland. Orthologous to human SLCO3A1 (solute carrier organic anion transporter family member 3A1). PHENOTYPE: Mice for a null endonuclease-mediated mutation exhibit shorter survival times, increased hepatic levels of bile acid, and develop more liver injury after induction of cholestasis. [provided by MGI curators] |