| Primary Identifier | MGI:95514 | Organism | mouse, laboratory |
| Chromosome | 7 | NCBI Gene Number | 14159 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 8.0.0) Enables microtubule binding activity and protein kinase activity. Acts upstream of or within centrosome cycle and microtubule bundle formation. Located in microtubule cytoskeleton. Is expressed in central nervous system and retina. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and lung adenocarcinoma. Orthologous to human FES (FES proto-oncogene, tyrosine kinase). PHENOTYPE: Homozygotes for a null allele show partial in utero lethality, runting, altered hematopoietic homeostasis and macrophage function, skin lesions and susceptibility to bacterial infection. Homozygotes for another null allele show enhanced LPS sensitivity, altered hematopoiesis and larger litter size. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
